Mattotti made his debut in the late 1970s as a comic book author and in the early 1980s he founded the Valvoline group with other illustrators. In 1984 he produced Fuochi, which was received as an event in the world of comics and won major international awards. He later published numerous comics, graphic novels and illustrated books, with various publishers: Coconino, Dolce Vita, Einaudi, Feltrinelli, Gallucci, Granata, Hazard, L’isola trovata, Logos, Louis Vuitton, Milano Libri, Nuages, Ottaviano. Today, his books are translated all over the world. He publishes in newspapers and magazines such as “The New Yorker”, “Le Monde”, “Das Magazin”, “Suddeutsche Zeitung”, “Nouvel Observateur”, “Corriere della Sera” and “la Repubblica”. His personal exhibitions have been numerous, including anthological exhibitions at the Palazzo delle Esposizioni in Rome, the Frans Hals museum in Haarlem, and the Musei di Porta Romana. His latest works include the publications Covers for the New Yorker and Ghirlanda for Logos and, in October 2019, the film presented at Cannes La famosa invasione degli orsi in Sicilia, based on the novel of the same name by Dino Buzzati. He lives and works in Paris.